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Los amantes del rock están de enhorabuena porque por XVII año consecutivo se celebrará un año más en Aguilar de Campoo el Festival Galleta Rock. El concurso tendrá lugar el sábado 28 de julio en la Plaza de España de la villa galletera y contará con la participación del grupo Lujuria como invitado. La organización, que ha recibido un total de 81 maquetas, está satisfecha por el alto nivel de participación del festival y…
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El agua como elemento indispensable para la vida se constituye como un servicio básico que debe prestarse con las máximas garantías de calidad. Actualmente las necesidades de agua aumentan, no solo el agua destinada al abastecimiento humano, sino también la destinada a sectores tan importantes como la agricultura, la ganadería y la industria, por lo que el agua se convierte cada vez más en un bien escaso.De esta manera, los municipios responsables del abastecimiento…
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Más de setenta artesanos procedentes de todos los rincones de la geografía palentina se darán cita en el Parque del Plantío de Cervera de Pisuerga el fin de semana del 28 y 29 de julio en la XIX Feria de Artesanía y Productos Agroalimentarios de la Montaña Palentina. Esta feria artesana, desmarcada de mercados temáticos y grandes empresas organizadoras, mostrará algunos de los oficios tradicionales de la Montaña Palentina. Los asistentes podrán comprobar en…
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Reinosa celebra este fin de semana uno de los acontecimientos más populares dentro del calendario festivo de la ciudad. Se trata del Mercado Campurriano, que en 2012, en su novena edición, volverá a conjugar gastronomía y cultura.Así, tal y como ha explicado el alcalde José Miguel Barrio y los concejales Ana Belén Tirado y José Andrés García, se darán cita en el entorno de la Plaza de España los alimentos más representativos de nuestra…
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Esta mañana el Presidente de la Diputación, José María Hernández durante la celebración del Pleno Ordinario en el apartado del Informe del Presidente, ha anunciado que el denominado Día de la Provincia 2012 – que pretende convertirse en una Jornada de trabajo y de reconocimiento de alcaldes, concejales, cargos públicos y a todos los ciudadanos de la provincia- se celebrará en la localidad palentina de Villamuriel de Cerrato durante la tarde del viernes,  28…
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Los ayuntamientos de la provincia de menos de 20.000 habitantes tienen de plazo hasta el próximo 1 de agosto para solicitar ayudas dentro de la convocatoria de Ayudas para garantizar las competencias de Protección de la Salubridad Pública en los Ayuntamientos mediante la Contratación de Trabajadores desempleados. La convocatoria salió publicada en el Boletín Oficial de la Provincia el pasado viernes, 20 de julio. El importe de la convocatoria alcanza los 200.000 euros. Las…
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Evidence of an immune-mediated, antitumor effect of PDE5 inhibition is further shown by tetramer analysis on splenocytes obtained from sildenafil-treated, CT26WT tumor- bearing mice, which revealed a higher number of CTLs specific for AH-1 (unpublished data), a CT26 tumor-associated antigen, as compared with their untreated counterparts (19). To confirm immune-mediated antitumor activity in the sildenafil-treated groups, we performed an in vivo cytotoxicity assay. BALB/c mice were injected with PBS (naive), vaccinated with -irradiated CT26WT or C26GM, or challenged with CT26WT or C26GM tumors on day 0. On day 12 (CT26WT) or day 5 (C26GM), all mice received carboxyfluorescein diacetate succinimidyl ester (CFSE)labeled splenocytes pulsed with the MHC class Irestricted AH-1 peptide (CFSEhigh), admixed with CFSE-labeled splenocytes pulsed with the irrelevant hemagglutinin (HA)-peptide (CFSElow). In vivo T cell cytotoxicity was determined 40 h later (Fig. 2). These time points were chosen based on the kinetics of tumor outgrowth observed in Fig. 1 A and Fig. 1 B, respectively, when tumor size significantly differed between untreated and sildenafil-treated mice. As expected, an endogenous AH1-specific immune response was observed in the vaccinated mice as compared with their tumor-bearing counterparts. PDE5 inhibition in the vaccine-primed mice failed to augment antigen-specific CD8 responsiveness compared with no treatment. In contrast, tumor-bearing mice treated with sildenafil early after tumor challenge generated antigen-specific immunity that was significantly greater then that observed in their untreated counterparts and similar, or even superior, to that induced by vaccination. Collectively, this is the first indication that PDE5 inhibitors can modulate antitumor immunity. Because the sildenafil-mediated antitumor immune response does not completely eradicate tumors, tumor escape mechanisms may be associated with their outgrowth. To test this hypothesis, the parental CT26WT cell line, as well as the CT26 tumor removed on day 24 from sildenafil-treated mice (either AH-1 pulsed or unpulsed), and BALB/c splenocytes were incubated with either AH-1 peptide-primed (Fig. S1 C) or tumor-primed (Fig. S1 D) effector T cells. Although effector T cells recognized the parental CT26WT line and released IFN- in the assay, they failed to recognize the sildenafil-derived tumor. Its recognition, however, was restored by loading the sildenafil-derived tumor with the AH-1 peptide. (Fig. S1, C and D). These results suggest that the immune response in sildenafil-treated mice does not result in complete tumor eradication but rather in the selection of antigen-escape variants. 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